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These cytokines act directly on skeletal muscle cells and activate multiple signaling pathways within the cell, further promoting protein degradation via the proteasome pathway and a calcium-dependent pathway [10, 11, 14]

This pathology was proposed to be due to a neurodevelopmental liability that results in a greater elimination of dendritic spine (pruning) during infancy and adolescence, but its molecular mechanisms are still unclear (Moyer et al., 2015)

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Oral L-citrulline and Transresveratrol supplementation improves erectile function in men with phosphodiesterase 5 inhibitors: a randomized, double-blind, placebo-controlled crossover pilot study

There are several investigational agents in clinical trials utilizing this approach (Table 5)

The role of nutrition in inflammaging